Ending Chronic Illness

The End of the Searching. The Beginning of the Healing.

From NYT bestselling author and internationally renowned physician Dr. Richard Horowitz comes a revolutionary roadmap to decode complex chronic illness and reverse inflammation from the inside out. This is a deeply hopeful, science-backed program for anyone who has been dismissed, misdiagnosed, or left exhausted by chronic illness.

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There’s A Reason You’re Still Sick

Symptoms Don’t Tell The Whole Story

Anyone living with chronic illness knows the cycle.

Symptoms that shift, flare, disappear, and return without warning.
Treatments that fix one problem while creating another.
Exhaustion. Pain. Brain fog. Inflammation.
Good days, bad days, and no way to make sense of the patterns.
Years spent searching for answers that never fully come.

While modern medicine has made some incredible advances, millions living with chronic illness are still left managing symptoms instead of understanding what’s actually driving them.

Dr. Richard Horowitz has made it his life’s mission to change that.

In Ending Chronic Illness, Dr. Richard Horowitz introduces his groundbreaking 16-point MSIDS framework designed to uncover the hidden factors that may be keeping the body stuck in a cycle of chronic inflammation, fatigue, pain, brain fog, immune dysfunction, and persistent illness.

Rooted in cutting-edge scientific research and decades of patient outcomes, this revolutionary work offers new insight into conditions spanning autoimmune diseases (like MS, rheumatoid arthritis, Crohn’s disease…), asthma/allergies, autism spectrum disorder, Alzheimer’s disease, ADD/ADHD, cancer, chronic fatigue syndrome, fibromyalgia, hormonal and neurological disorders, GI dysfunction, chronic pain, Chronic Lyme disease and associated tick-borne disorders, immune dysregulation with environmental toxicity, mood disorders, and more.

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Save 15% on your Bookshop order with code RICHARD15

The Book That Connects The Dots

Bringing together decades of clinical experience, scientific research, and real patient outcomes, this practical and deeply hopeful guide helps readers better understand why so many people remain sick despite “normal” testing or symptom-based treatment alone.

Inside, you’ll discover:

Why inflammation keeps coming back, and what may be driving it
The hidden factors behind symptoms that never seem to fully resolve
How infections, toxins, stress, and immune dysfunction work together to keep the body stuck
A deeper understanding of the groundbreaking MSIDS model
Guidance on testing, diagnostics, and where to look next
Practical strategies to improve sleep, lower stress, and support recovery
Evidence-informed natural therapies and treatment approaches
A more complete roadmap for understanding chronic illness and healing from the inside out

“Horowitz is one of the most prominent ‘Lyme Literate’ physician…patients wait for months to see him, and several told me that he had essentially cured them of a disease that nobody else seemed able to treat.”

A New York Times Bestselling Doctor, Dr. Richard Horowitz

Dr. Richard Horowitz is a board-certified internist and internationally recognized expert in Lyme disease and complex chronic illness. Widely considered one of the country’s foremost authorities on chronic disease, he has spent more than four decades helping patients uncover the hidden causes behind persistent illness and inflammation.

Dr. Horowitz is the creator of the pioneering MSIDS (Multiple Systemic Infectious Disease Syndrome) model, a groundbreaking framework designed to identify the multiple overlapping factors contributing to chronic illness, and uncover what may truly be driving disease.

He is also the author of the New York Times bestselling books Why Can’t I Get Better?, often referred to as “The Lyme Bible,” How Can I Get Better? and Ending Chronic Illness. He has served as a consultant and educator to governments, healthcare professionals, and organizations worldwide.

Above all, Dr. Horowitz has dedicated his life to helping chronically ill patients find answers, hope, and a path forward.

Dear friends,

I am thrilled to let you know that my new book, “Ending Chronic Illness: A Revolutionary New Program To Reverse Inflammation And Heal Persistent Disease” by Simon & Schuster is now available for preorder at all major book publishing sites and will be released on October 13, 2026. Why am I so excited about my new book and how is this book different than my two prior New York Times/National Bestsellers (Why Can’t I Get Better? and How Can I Get Better?) which provided a comprehensive plan for the diagnosis and treatment of tickborne disorders?

Start Here

The groundbreaking bestseller that introduced the revolutionary MSIDS model and helped thousands of patients finally connect the dots behind chronic Lyme disease, inflammation, and complex chronic illness.

A practical, real-world action plan for patients and practitioners navigating treatment-resistant chronic illness and the many hidden factors that can block healing and recovery.

For The People Still Searching For Answers

If you’ve spent years exhausted, dismissed, misdiagnosed, or stuck managing symptoms without understanding what may be actually driving them, Ending Chronic Illness was written for you.

Using his field-defining MSIDS model, Dr. Richard Horowitz helps uncover the hidden factors behind persistent inflammation, offering a more complete approach to understanding chronic illness and why so many patients remain stuck for years without clear answers.

More importantly, this book offers something many patients have been missing for far too long: a clearer path forward and renewed hope for healing and recovery.

There is Hope.

More than half of Americans are living with chronic illness, many without real answers or lasting relief. Ending Chronic Illness is designed to help patients ask better questions, connect the dots behind chronic disease, and identify what may truly be driving illness.

Because real healing starts with finally understanding what your body has been trying to tell you all along.

Dear friends,

Chronic diseases are now affecting up to 60% of all Americans and over half of the people living on the planet right now, with up to 25% of American suffering from 2 or more chronic illnesses. Up to 86% of our healthcare costs and 70% of the deaths in the United States are due to chronic illness and yet we don’t have a comprehensive model to address the underlying causes of why so many of us are getting sick and staying ill. Ending Chronic Illness is the first book ever to show that all 16 MSIDS factors that I discovered underlying chronic Lyme disease, also applies to most chronic illnesses affecting humanity. I had previously published this groundbreaking research in the medical literature for chronic Lyme disease, Long Covid and recently even Alzheimer’s dementia! Ending Chronic Illness goes beyond these three major diseases and shows you how using the 16 point MSIDS model gives us a brand-new way of preventing, diagnosing and solving the problem of chronic illness by finding what triggers the root cause: multiple sources of inflammation. Inflammation has been found to underlie all chronic disease, but where is the inflammation coming from and how can we best address it with diet, exercise, natural solutions, and not just pharmaceuticals?

The prevention, diagnostic and treatment approaches that you will read about in Ending Chronic Illness address a wide range of common but challenging conditions. Even if you are suffering from one of the diseases listed below and have gotten help with medication, wouldn’t you like to know how to potentially improve your condition and not necessarily need some medication that may carry long-term risks? While also understanding how to best support your health so you and your loved ones may not necessarily develop certain chronic conditions?

Ending Chronic Illness provides an innovative, science-based approach to a broad range of chronic diseases, including but not limited to autoimmune diseases, allergies, asthma, Autism spectrum disorder (ASD), ADD/ADHD, chronic pain syndromes, Chronic Lyme disease/PTLDS and associated co-infections, Long Covid, Chronic fatigue syndrome/ME, Fibromyalgia, Multiple sclerosis, Alzheimer’s dementia, cancer, cardiovascular disease, digestive disorders, hormonal dysfunction, immune dysregulation, environmental toxicity, mood and sleep disorders, and more.

– Ending Chronic Illness provides diagnostic solutions to discover why you became ill and are still sick

– Incorporates cutting-edge treatment solutions with both classical and functional medicine/natural approaches

– Provides a wellness map to stay healthy in a world filled with infections and toxins

– Provides true hope for a brighter and healthier future!

My new handbook will guide you as well as your healthcare team in creating a comprehensive diagnostic and treatment plan, supporting your health. It will also give you a better understanding of all of the new science on pulsing and persister protocols that are so effective in treating chronic Lyme and associated co-infections like Bartonella with detailed instructions on how to do them. I updated Ending Chronic Illness with a chapter on the 3 Bs (Borrelia, Babesia, Bartonella) and explain new ways of using lower, slower dapsone combination therapy to ensure you take advantage of the most effective, shortest, oral, generic protocol available to help you get your health back!

Please pre-order my new book, Ending Chronic Illness at any of the sites below and consider getting copies for your friends, family and healthcare team. They will thank you for it! If you put the code Richard15 in bookshop.org during the check out, you can get 15% off.

Wishing you the best of health!

Dr Richard Horowitz